Local Anesthetic Activity of 1-(Morpholino or Piperidino)-2-Propanol Derivatives
نویسندگان
چکیده
منابع مشابه
Local anesthetic activity of 1-(morpholino or piperidino)-2-propanol derivatives.
The local anesthetic activities of 1-(morpholino or piperidino)-2-propanol derivatives were investigated. These activities were observed with nerve trunk anesthesia, rabbit's corneal anesthesia and intradermal injection anesthesia. Among these propanol derivatives, No. 24 and No. 25 which possess thioether-type sulfur were the most active and the effective potency was enhanced by increasing the...
متن کامل1-phenyl-2-decanoylamino-3-morpholino-1-propanol chemosensitizes neuroblastoma cells for taxol and vincristine.
In this study, we show that an inhibitor of glycosphin-golipid biosynthesis, D,L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), increases the chemosensitivity of neuroblastoma tumor cells for Taxol and vincristine. At noneffective low doses of Taxol or vincristine, the addition of a noneffective dose of PDMP resulted in 70% cytotoxicity, indicating synergy. Such an effect was no...
متن کاملNew 1-aryl-3-substituted propanol derivatives as antimalarial agents.
This paper describes the synthesis and in vitro antimalarial activity against a P. falciparum 3D7 strain of some new 1-aryl-3-substituted propanol derivatives. Twelve of the tested compounds showed an IC(50) lower than 1 microM. These compounds were also tested for cytotoxicity in murine J774 macrophages. The most active compounds were evaluated for in vivo activity against P. berghei in a 4-da...
متن کاملReproductive toxicology. 1-Chloro-2-propanol.
1 Department of Bioengineering, University of California San Diego, La Jolla, CA, USA and 2 Institute for Nonlinear Science, University of California San Diego, La Jolla, CA, USA 3 These authors contributed equally to this work 4 Present address: Institute for Systems Biology, Seattle, WA 98103, USA * Corresponding author. Department of Bioengineering, University of California San Diego, 9500 G...
متن کامل1-[Morpholino(phenyl)methyl]-2-naphthol
There are two independent mol-ecules in the asymmetric unit of the title compound, C(21)H(21)NO(2), which was synthesized by the one-pot reaction of 2-naphthol, morpholine and benzaldehyde. The dihedral angles between the naphthalene ring systems and the benzene rings are 84.03 (7) and 75.76 (8)° in the two mol-ecules and an intra-molecular O-H⋯N hydrogen bond occurs in each independent mol-ecule.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1975
ISSN: 0021-5198
DOI: 10.1254/jjp.25.563